MBI 111 Lecture Notes - Lecture 10: Adaptive Immune System, Antigen-Presenting Cell, Phagolysosome
27 Apr 2016
School
Department
Course
Professor
Document Summary
Interferons: antiviral proteins produced by virally infected cell to protect neighbors from viral multiplication. Phagocytosis: phagocytes: white blood cells (wbc)"s that carry out phagocytosis. Travel through the bloodstream and enter tissues to fight infection. Removes microbes, harmful substances, and dead phagocytes and tissue cells: phagosome: membrane-bound compartment containing the microbe, phagolysosome formation. Phagosome ten fuses with lysosomes forming phagolysosome contains antimicrobial chemicals: complement: group of 26+ proteins found in blood, complement action forms membrane attack complexes on surface of bacterial and viruses cells leading to rupture. Fever: pamps and damps lead to an immune response involving cytokine production. Leads to an increase in body temp: symptoms=redness, heat, swelling, pain, fluids leak from the blood through blood vessel walls into the area (swelling, pain, chemotaxis: phagocytes are attracted to site of infection. Phagocytes roll through fluid because it is so sticky and squeeze through blood vessel walls: a pus-filled area or cavity may form.
