ANP 330 Lecture Notes - Lecture 61: Peptic Ulcer, Gastric Mucosa, Gastroenterostomy
ANP 330 Lecture 61
Most common stomach d/o
Peptic ulcer Disease (PUD)
Peptic Ulcers are responsible for up to 50% of all upper GI bleeding episodes
Increases risk for Peptic ulcer disease
Most prevalent in people age 40 - 60
Familial link, more common in people with blood Type O
Increased incidence with COPD & renal disease
Peptic ulcer Disease
Characterized by erosion of GI mucosa resulting from the digestive action of HCL
acid & pepsin.
Can occur in any portion of GI tract comes in contact with gastric secretions
Lower esophagus, stomach, duodenum, or jejunum after surgical procedure
(gastroenterostomy)
Approximately 10% males & 4% women will have ulcers during their lifetime.An open
sore/raw area in the lining of the upper part of the small intestine or the stomach.
PUD refers to ulcerations that can develop in any portion of the GI tract that is
exposed to acid and pepsin in sufficient concentration and duration to produce a
break in the mucous membrane. By definition, a peptic ulcer penetrates beyond the
submucosa into the muscu- laris mucosa.
Acute vs Chronic peptic ulcers
Acute- superficial erosion & minimal inflammation of mucosa. Short in duration &
resolves quickly when cause identified & removed.
Chronic-long duration, eroding through muscular wall & formation fibrous tissue.
Depending on degree of mucosal involvement acute or chronic. Chronic ulcer-
present for many months or intermittently thoroughout a person's life. 4X more
common than acute.
Causes of peptic ulcers
Drugs, aspirin, NSAIDs,
Viral Infection (H-pylori), bacterial infection. H Pylori is most common cause. 95%
Ischemia
