CHE 210 Lecture Notes - Lecture 2: Acid Dissociation Constant, Gastric Mucosa, Lewis Acids And Bases
Chapter 03: 1
1) Rank compounds A through D from least to most acidic.
O
O
CH
2
H
A
O
CH
B
O
H
C
H
D
O
OH
pKa 19.3
pKa 9
pKa 9.9
pKa 4.8
<<<
Most
Least
2) Identify the least and most acidic compounds.
ABCD
N
HH
N
HH
Most
Least
3) Rank compounds A through D from least to most acidic.
A B C
O
H
O
H
Cl
Cl
Cl
O
H
<<
Most
Least
Chapter 03: 2
4) Given the following pKa values for the following compounds, rank their conjugate bases (A – D)
from least to most basic.
CCH
H
HNH
H
OH
OH
pKa 25
pKa 38
pKa 18
pKa 16
A
B
C
D
CC
H
HN
H
O
O
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Most
Least
OH
HOH
H
HOH
Cl H
pKa –2.9
pKa –1.74
pKa 15.7
pKa –7
A
B
C
D
O
HOH
OH
Cl
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Most
Least
5) Rank the compounds according to acidity of the highlighted H.
TRY IT WITHOUT pKa VALUES
A
B
C
D
N
H
H
H
N
H
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Most
Least
Document Summary
Chapter 03: 1: rank compounds a through d from least to most acidic. Most: identify the least and most acidic compounds. Most: rank compounds a through d from least to most acidic. Chapter 03: 2: given the following pka values for the following compounds, rank their conjugate bases (a d) from least to most basic. Cl: rank the compounds according to acidity of the highlighted h. Chapter 03: 3: draw one arrow in the box to indicate the favored direction of the acid/base reaction at equilibrium. O h pka 16: draw one arrow in the box to indicate the favored direction of the acid/base reaction at equilibrium. pka = 15. 7. O pka 9. 9: draw one arrow in the box to indicate the favored direction of the acid/base reaction at equilibrium. Oh pka 25: draw one arrow in the box to indicate the favored direction of the acid/base reaction at equilibrium.
