MMG 301 Lecture Notes - Lecture 21: Ames Test, Repressor Lexa, Http Cookie

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Lecture 21: compare and contrast selectable and non-selectable mutations. Selectable- confer a clear advantage to the organism in certain conditions. Non-selectable- do not confer a particular advantage to the organism: compare and contrast the three types of point mutations. Silent: explain what a mutagen is. The radiation of chemicals that increase mutation rates in dna: compare and contrast same-site and second-site reversions. Same site- the mutated base pair mutates back to original genotype. Second-site- mutation at different site restores the original phenotype: explain why deletions and insertions can have dramatic effects on protein sequences. It changes the reading frame: explain how reca and lexa regulate each other in the sos repair pathway. Activated reca degrades lexa: explain what the ames test is used for. Measures the rate of reversion mutations: explain how the ames test is performed. Bacterial strain used contains a point mutation in a gene involved in histidine synthesis. Bacteria plated on agar growth medium containing no histidine.

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