MICROB 3200 Lecture Notes - Lecture 3: Bifidobacterium, Leptin, Precision Medicine
Document Summary
Within the human body, microbial cells are estimated to outnumber human cells by 3-10 to 1. Total number of genes may exceed the human content by 100-300 to 1. Many of these bacterial species have not been cultured in the laboratory and thus their potential role in human physiology and disease is largely unkown. Major initiative from nih to catalog the human microbiota and initiate the investigation of its role in human health and disease. Gi (30%); oral (26) skin (21); airways (14); urogenital (9); blood (1); The human gi tract contains 1000 or more phylotypes (or species) - oral and genital tracts and skin probably double this number. Each individual human is populated with a unique diversity of flora. Unnatural (anthrogenic) selection is the main force in bacterial evolution over the past 200 years. Relative abundance of 6 dominant bacterial phyla from groups of healthy human volunteers.
