BIO 320 Lecture Notes - Lecture 4: Wound Healing, Granulation Tissue, Focal Adhesion
Document Summary
1st - what happens in a surgical resection. Can be approximated which gives the greatest opportunity of re-epithelialization. Will make a fresh cut on either side of the wound and then try to reapproximate. They take a 2nd wound and try to convert into a 1st wound. Renewing tissue: complete regeneration, epidermis, gi tract epithelium, hematopoietic system (blood cell producing, very little to no scaring, most if not all functionality returns. Stable tissues: compensatory growth of b liver and kinder. Role of extracellular matrix in regeneration and repair. Liver regeneration with restoration of normal tissue after injury requires an intact cellular matric. If matrix is damaged the injury is repaired by fibrous tissue deposition and scar formation. General patterns of intra signaling demonstrating autocrine(self), paracrine (one cell to another), and endocrine (sends through the bloodstream) signaling. Both epithelial and mesenchymal cells (fibroblasts) interact with ecm via integrins.
