BIO 183 Lecture Notes - Lecture 25: Monosomy, Chloroplast, Amniocentesis

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bronzegoose791

25 Apr 2017

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Discovered mutant male fly w/ white eyes instead of red. Non-mutant type = wild type, in this case red eyes. Test cross take trait you know is dominant and test it. Sex-linked traits - alleles are on sex chromosomes (ex: female birds are less colorful) Sex determination in drosophila is based on # of x chromosomes. Sex determination in humans also based on presence of y chromosome. Certain genetic diseases affect males to a greater degree than females. Disease that affects the blood"s ability to clot. Ensures an equal expression of genes from sex chromosomes even though females have 2 x chromosomes and males only have 1. In each female cell, 1 x chromosome is inactivated and highly condensed into a barr body. Females heterozygous for genes on the x chromosome are genetic mosaics. Traits controlled by these genes do not follow the chromosomal theory of inheritance.

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The following question is a sex-linked trait. Review the patterns of inheritance of sex-linked traits before answering the following questions. Make sure to indicate chromosomes and alleles in your answers when necessary.

Hemophilia is a caused by a recessive mutation found on the X chromosome in humans. The recessive allele (X^h) is associated with abnormal blood clotting (hemophilia), while the dominant allele (X^N) causes normal blood clotting.

A man with normal blood clotting and woman who is heterozygous are going to have a child. What is the probability of an offspring who is a carrier of hemophilia, and if so, the sex(es) of the offspring?

A. Chances are 25% of a son who is a carrier

B. There is no chance of an offspring who is a carrier

C. Chances are 50% of either a son or a daughter who is a carrier

D. All offspring, male or female, will be carriers

E. Chances are 1 in 4 of a daughter who is a carrier

2. Two fruit flies, one with red eyes and one with white eyes mate and have an offspring with white eyes. Having red eyes is a dominant trait (R) while white eyes (w) is recessive. Based on this information, what must be the genotypes of the parental white-eyed fruit fly and the parental red-eyed fruit fly?

A. Red-Eyed fruit fly: Rw

White-eyed fruit fly: ww

B. Red-Eyed fruit fly: RR

White-eyed fruit fly: wR

C. Red-Eyed fruit fly: R

White-eyed fruit fly: w

D. Red-Eyed fruit fly: rr

White-eyed fruit fly: wr

E. Red-Eyed fruit fly: RR

White-eyed fruit fly: ww

Please explain, and no hand-written work please, please type answer

Sex-Linked Traits (traits located on the sex chromosomesâusually the X chromosome)

Follow the directions for the lab. Enter data you obtain for the following crosses and answer questions on this answer sheet. (NOTE: The traits used in this Module 3 Lab are sex-linked. Therefore, you CANNOT click the âignore sexâ button for these crosses. You need to see separate results for males and females to analyze data for sex-linked traits.)

Question: In this lab exercise, should you click the "ignore sex" button for the crosses?

1. a. Perform a monohybrid cross between a female fly with a tan body and a wild-type male fly. Show results for the F₁ offspring. (NOTE: You will use these F₁ flies in the next cross.)
ENTER DATA HERE:

Question: Are the phenotypes of the F₁ offspring what you would have predicted for this cross: why or why not?

Question: Each F₁ female received a tan allele from her mother and a wild allele from her father. Why do all of the F₁ females show the wild-type phenotype?

Question: Compare the number and type (X or Y) of sex chromosomes found in female and male flies.

Question: Compare the number of alleles present on the X and Y chromosomes.

Question: How can you tell that tan body is a sex-linked trait?

Question: How can you tell whether tan body is located on the X chromosome or the Y chromosome?

Question: If tan body was located on the Y-chromosome, what would be the phenotype of all the male F₁ offspring? Is this what you obtained for the cross above?

Question: If tan body was located on the Y-chromosome, could females even show the trait? (HINT: When analyzing the cross results, remember that Y-linked traits are passed down only from affected males to their sons. Females cannot display Y-linked traits since they do not have Y chromosomes. On the other hand, both males and females can inherit X-linked traits since they both have X chromosomes.)

PUNNETT SQUARE:

List the genotypes of the parent flies in this cross (HINT: You must use X and Y symbols):

List the gametes produced by each parent fly in this cross:

Show the Punnett Square for the above cross.

1. The eye color of wild-type Drosophila flies is red. Differentmutations in a single or in multiple genes lead to flies with whiteeyes. Mutations in the w gene on the X chromosome lead to whiteeyes instead of the normal red. You have isolated both a white-eyedmutation (designated W-1) that gives a dominant phenotype, and awhite-eyed mutation (designated w-2) that gives a recessivephenotype.

(a) A white-eyed male from the W-1 line is crossed to awild-type female. What color eyes will the female progeny from thiscross have?

(b) What color eyes will the male progeny from the cross in part(a) have?

(c) One of the female progeny from the cross in part (a) ismated to a white-eyed male from the w- 2 line. What fraction of thewhite-eyed progeny from this cross will be female?

2. The body color of Drosophila adult flies is regulated bymultiple genes, including the autosomal ebony gene. Ebony body (e)is recessive to the wild type (yellowish) body (e+). A second gene,which is X-linked, controls bristle shape. Normal bristle shape(f+) is dominant to the mutant forked bristles (f). A female withforked bristles that is heterozygous for the body color gene ismated with an ebony body male (his bristles are normal).

(a) What are the genotypes of the parents?

(b) Using a Punnett square, determine the expected proportionsof each possible progeny phenotype. Since there is a sex-linkedgene here, be sure to include consider sex as part of thephenotype.

3. Describe in your own words what a balancer chromosome is andwhy it is important in fly genetics (you will have to do someresearch for this one!)

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BIO 183 Lecture Notes - Lecture 25: Monosomy, Chloroplast, Amniocentesis

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