GN 311 Lecture Notes - Lecture 9: Cri Du Chat, Susumu Ohno, Haploinsufficiency
Document Summary
Change in gene frequency depends on migration rate and on the gene frequency of the immigrants vs. natives. P: frequency of a allele in the donor population (mainland) M: proportion of migrants after immigration occurred = probability that a parent will come from the mainland. If you i(cid:374)itially ha(cid:448)e (cid:1005)75 i(cid:374)di(cid:448)iduals a(cid:374)d the(cid:374) (cid:1006)5 (cid:373)ig(cid:396)ate i(cid:374) : m= immigrants/total = 25/(175+25) = 0. 125. P: frequency of a allele on island initially. 1-m: probability that a parent will come from the island. P": f(cid:396)e(cid:395)ue(cid:374)cy of a allele after migration: p" = ((cid:1005)-m)p + mp (like a weighted average) Have to have a centromere to remain a chromosome and remain in the cell: terminal deletion, at the end. In the middle somewhere: the child(cid:396)e(cid:374)"s c(cid:396)ies sou(cid:374)d like cats, a deletion on a chromosome where they are missing a short arm of chromosome #5, this (cid:449)ill (cid:396)esult i(cid:374) (cid:862)compensation loops(cid:863) i(cid:374) (cid:373)eiosis.
