GN 301 Lecture Notes - Lecture 16: Narcolepsy, Apolipoprotein E, Mutation
Document Summary
Intelligence disability: disability that occurs during developmental lifetime of a person, 3% affected (450k in nc and 15 mil around world, causes, 37% genetic, polygenetic inheritance, could inherit combo of all the bad alleles. Familiar intellectual disabilities: 75% of cases come from 10% of families. Fat builds up and causes blindness, paralysis, convulsions: rett syndrome, x-linked dominant, chromosomal: trisomy 21, 18, 13, (cid:1009)(cid:1004)% of triso(cid:373)(cid:455) (cid:1005)(cid:1012) die i(cid:374) uterus a(cid:374)d (cid:1013)(cid:1004)% do(cid:374)"t li(cid:448)e lo(cid:374)ger tha(cid:374) (cid:455)ear. Fragile x syndrome: william syndrome, deletion from chromosome 7, 20% environmental, prenatal. Infections: measles, hiv, herpes: medicines, drugs, alcohol, maternal health: bp, diabetes, nutrition, can decrease iq potential by 7 units, perinatal, at delivery, oxygen deprivation (more than 90 seconds, premature delivery (less than 5. 5 lbs) Low birth weight correlated with lower iq: postnatal. Sudden short but deep sleep: polygenic in humans and requires env triggers, more likely to have car accident, cataplexy. Shrinking cortex, dead brain cells, big fatty deposit.
