BIOS10115 Lecture Notes - Lecture 19: Severe Acute Respiratory Syndrome, Flu Season, Bacterial Pneumonia
3 Dec 2016
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Continued notes: most common infectious disease, usually rhinovirus (115 serotypes), also corona, adeno, and others, self limiting, can alleviate symptoms antihistamines, decongestants, etc, etiology too complex for vaccine development. ~8100 infected 774 died, no deaths in u. s. No new cases (naturally caused) since july, 2003. Spike (s) protein allows attachment to cells. Fever, chills, fatigue, headache, achiness, malaise lasting 3-7 days. (can be several weeks before complete recovery) 3-5 million cases and 250,000 to 500,000 deaths/year worldwide (seasonal influenza) Stomach flu not really a flu. 3 main types a, b, and c. Surface antigens: hemagglutinin (h) attaches to receptors on host cells, neuraminidase (n) penetration of mucus layer. If more than one virus infects a single cell, rearrangement of segments can occur. Antigenic drift: minor changes in surface proteins (point mutations, new antibodies may be needed, localized epidemics. Antigenic shift: re-assortment of viral genes leading to new strains. More than one strain infecting a cell.
