CHEM46497 Lecture Notes - Lecture 16: Enzyme Inhibitor, Glycolysis, Isocitrate Lyase
Document Summary
Study guide chapter 16 citric acid cycle. Be able to trace out the citric acid cycle from pyruvate to acetyl-coa and through the complete cycle. In the cycle be able to name and give the structures of every intermediate, give the name of every enzyme, locate all the steps where nadh, Locate the reactions where you have the most favorable large negative (cid:0) g , and the reactions that are control points. Understand how the tca pushes or pulls reactions through steps with unfavorable (large positive (cid:0) g ) . Citric acid cycle takes place in the matrix of the mitochondria. Pyruvate goes through the pdh complex (e1, e2, e3) to make acetyl coa and. Uses nad+ as the oxidizing agent: delta g is high 29. 7 kj/mol driven by citrate synthase using up oxaloacetate quickly and by reducing nad+ Tracking carbons both carboxylic acid groups on oxaloacetate will be lost as co2, replaced with the carbons from acetyl coa.