GENE 500 Lecture Notes - Lecture 1: Conformational Change, Covalent Bond, ProlinePremium

2 pages101 viewsFall 2018

School

Department

Genetics

Course Code

GENE 500

Professor

Lawrence Grossman

Lecture

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Lecture 1 - Protein Structure

These functions summarize the main functions of the

proteins → Proteins develop many of these diverse

functions through exploiting a few simple activities: Most

fundamentally, proteins bind—to one another, to other

macromolecules such as DNA, and to small molecules

and ions. In many cases, such binding induces a

conformational change (a change in the three-

dimensional structure) in the protein and thus influences

its activity. Linear chains of amino acid building blocks

are arranged in a three-dimensional structural hierarchy.

Protein Hierarchy

A key concept in understanding how proteins work is that function is often derived from three-

dimensional structure, and three-dimensional structure is determined by both a protein’s

amino acid sequence and intramolecular noncovalent interactions.

Primary Structure – individual amino acids are linked together in linear, unbranched chains by

covalent amide bonds, called peptide bonds → form via reactions that result in a loss of water

(dehydration)

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