BMCB 658 Lecture Notes - Lecture 23: Carnitine O-Palmitoyltransferase, Chief Operating Officer, Insulin
Document Summary
April 19, 2016: pyruvate dehydrogenase complex (mitochondrial matrix, fatty acid oxidation (mitochondrial matrix, amino acid degradation. Citrate splits back into acetyl-coa + ooa. Acetly-coa needs to be transported into cytosol from maxrix. Acetyl-coa condenses with oxaloacetate to form citrate. Citrate can cross both of the mitochondrial membranes to the cytosol. Splits to form acetyl-coa + oxaloacetate in cytosol. Citrate can pass inner mitochondrial membrane to cytosol. Malate can cross the inner membrane, but it doesn"t. Pyruvate can transport: it remains in cytosol to be converted to pyruvate to make nadph. Oxaloacetate reactions that produces nadph (which is needed for fatty acid synthesis) Malonyl-coa is key intermediate in fatty acid synthesis. Malonyl-coa inhibits carnitine acyltransferase i: prevents futile cycle. Next: successive additions of 2-carbon units: 2 of the 3 carbons in malonyl-coa, requires multi-enzyme complex: fatty acid synthase, repeats until 16:0 formed (palmitate) Note both are linked to fatty acid synthase via thioester bonds.