BIOL 1119 Lecture Notes - Lecture 8: Mean Arterial Pressure, Hypertension, Vascular Resistance

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Karina Da Rosa
1. Blood Pressure and Flow
a. Blood flow
i. Principles of blood flow
1. Blood flow
a. Amount of blood flowing through tissue in a given time
2. Velocity
a. Distance traveled by blood per unit time
b. You can have the same flow rate in two different places but
the velocities of the blood are different
3. Perfusion
a. Rate of blood flow per given mass of tissue
b. A large organ can have a higher rate of flow but less
perfusion than a smaller organ
c. Total flow is equal to cardiac input
i. May vary depending on demand
4. Hemodynamics
a. Physical principles of blood flow based on pressure and
resistance
b. F = ΔP/R
i. Flow = change in pressure over resistance of flow
b. Blood pressure
i. P = F/A
1. Pressure = force over area
ii. Force of blood applied to any vessel wall
iii. Type of hydrostatic pressure
1. Compressed pressure
2. Systolic vs diastolic
a. Systolic
i. Highest of ventricular systole
b. Diastolic
i. Lowest during ventricular pressure
3. Mean arterial pressure (MAP)
a. Also known as systemic blood pressure
b. Pressure driving blood into the tissues averaged over the
entire cardiac cycle
c. Not an arithmetic average of diastolic and systolic pressure
i. Low diastolic lasts longer than systolic pressure
d. Similar in all of the large arteries
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