PSYC 3406 Lecture 9: Lecture 9 - Suicide cont.
6 Jun 2018
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Impact Factor → How well-known/prestigious the journal that it was published in was
● High Impact Factors:
○ New England Journal of Medicine
○ Nature
○ Science
● More than 90% of subjects who committed suicide met criteria for at least one major
psych diagnosis
● Half of these subjects had psych disorder for at least 2 years
● Link between psychopathology and suicide
Hypothalamus
● AVP (vasopressin), OXT (oxytocin), and CRF (corticotropin releasing factor)
○ AVP high → increases aggression
○ OXT low → prosocial engagement (is low)
○ CRF high → stress
Amygdala
● 5-HT, DA, GABA, and Glutamate
○ 5-HT low
○ DA high → high levels of motivation and arousal, sometimes people feel really
good before they commit suicide (euphoria)
○ GABA no change → if high or low, the release of other neurotransmitters would
change
○ Glutamate high → inhibits 5-HT release, promotes DA release
Organized Plan, Intent, Preparation
● One in four adolescents that completed suicides show evidence of planning
● According to Shaffer the time-honored clinical inquiry about planning is a poor measure
of serious intent
○ Low amount of people who have a plan actually follow through
Important Implications
● Need for thorough diagnostic interview
● Never discount a threat especially in the context of affective or substance abuse
disorders
○ Anxiety
○ Depression
● Importance of aggressive intervention in first-episode affective illness
● The most common diagnostic groups were mood disorders (52% major depression),
disruptive disorders (ADHD, Intermittent Explosive Disorder, conduct disorder
(pyromaniacs)) and substance abuse (SUDs - Substance Use Disorders)
find more resources at oneclass.com
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Document Summary
Impact factor how well-known/prestigious the journal that it was published in was. More than 90% of subjects who committed suicide met criteria for at least one major psych diagnosis. Half of these subjects had psych disorder for at least 2 years. Avp (vasopressin), oxt (oxytocin), and crf (corticotropin releasing factor) Oxt low prosocial engagement (is low) Da high high levels of motivation and arousal, sometimes people feel really good before they commit suicide (euphoria) Gaba no change if high or low, the release of other neurotransmitters would change. Glutamate high inhibits 5-ht release, promotes da release. One in four adolescents that completed suicides show evidence of planning. According to shaffer the time-honored clinical inquiry about planning is a poor measure of serious intent. Low amount of people who have a plan actually follow through. Never discount a threat especially in the context of affective or substance abuse disorders. Importance of aggressive intervention in first-episode affective illness.
