BIOL SCI 150 Lecture Notes - Lecture 21: Wnt Signaling Pathway, Ovarian Cancer, Pancreatic Cancer
16 Mar 2018
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Cancer rates goes up by the sixth power of age [age]^6. Generating a lethal tumor is a multi-step process. Small amount of pediatric cancers (cid:840)ex: leukemias, ameloblastoma(cid:841) Lower rates in elderly due to eventual death. Melanoma incidence strong influence of race (cid:840)gene/environment interaction(cid:841) Success story treatment is successful if melanoma is caught before metastasi ed. Higher rates in white individuals (cid:840)in the sunshine and light skinned(cid:841) worst in australia (cid:840)group from great britain(cid:841) Pancreatic cancer, ovarian cancer most likely fatal. About 20 years of exposure, the cancer deaths expose themselves. Over time, lung cancer rates went down as did cigarette consumption (cid:840)less prevalent(cid:841) Being mutant for either brca1 or brca2 dramatically increases cancer risk and shifts the onset of breast cancer by 20 years. If you are mutant you skip a step in the multi-step process of developing cancer. Like skin, it is an interaction with the outside world. Cells can only be subjected to that for so long.
