BIOL SCI 215 Lecture Notes - Lecture 24: Mutation, Cellular Differentiation, Zygosity
21 May 2016
School
Department
Course
Professor
Document Summary
Mutations in one gene is not more likely than in another gene. More severe mutations would likely be lethal in early embryos. Not all genetic diseases are inheritable- example, cancer- anyone can get it even if it doesn"t run in the family. Cancer is hard to tackle because it"s our own cell- killing cancer can kill our own cell. Cancer is different from person to person (it"s genetic and everyone has different genetics) Environmental (carcinogens), spontaneous (replication errors), genetic risk factors (heterozygosity) mutations. Dna repair, immune system, cellular checkpoints/programmed cell death (make sure cells die when they are supposed to- cells are asked to commit suicide) Uncontrolled cell division, de-differentiation, metastasis-cell becomes invasive, learns to move around and affect other areas. Cigarette smokers: 1mutation/15 smokes, damages dna, build up carcinogens in lungs. Additional enzymes feel for mis-matches- mis match repair. 95% of chronic myelogenous leukemia (cml) patients have a translocation.
