PSYCH 212 Lecture Notes - Lecture 14: Psychopathology, Spatial Memory, Cell Migration

• School: Northwestern University
• Department: Psychology
• Course: PSYCH 212
• Professor: Robin Nusslock

Document Summary

Bipolar disorder associated with elevated reward-related brain-function hypersensitivity to reward. Risk for mania excessive increase in approach affect re ected in hypo/manic symptoms. Reward-related brain function as biological marker of differential risk for depression, bipolar disorder, and anxiety. When depressed individuals look at something positive they dampen their positive emotions depressed individuals down-regulate" positive emotion. Excessive anxiety, fear, neuroticism, and behavioral inhibition involves too much amygdala activation during fear acquisition and too little top-down regulation of amygdala by the vmpfc during fear extinction. Depression associated wth reduced structural integrity in uncinate fasiculus connection. Pfc and amygdala ie poor to-down regulation psychopathy - lack of remorse, callousness/lack of empathy, glibness/super cial charm, grandiose sense of self worth, and pathological lying single best predictor of recidivism. Individuals with callous-unemotional style (ie psychopathy) have reduced amygdala activation to fear stimuli psychopaths show limited conditioning in the amygdala.