BIOL-UA 22 Lecture Notes - Lecture 9: Dynamin, Triskelion, Clathrin
18 Mar 2016
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Lecture 9: cell compartments iv: endocytosis and lysosomal targeting. Topic: when proteins are marked to go to the lysosome for degradation. Anterograde transport of protein from cis to trans. How the cell get"s a lot of macromolecules. Low density lipoproteins with big molecular complexes that cannot be transported through the plasma membrane need endocytosis. Slide 3: the trans-golgi network is a sorting platform . Sorting platform = a place where you have many different types of vesicles destined to go to different locations (er has only one destination) Different coats help vesicles fuse to their specific destinations. Ap & clathrin = that fuse together to help form the lysosome. Slide 4: 36 clathrin triskelions form a polygonal lattice with intrinsic curvature that coat a vesicle. Light chain = involved in protein-protein interaction. (1) the triskelion structure is the building block for the soccer that shapes the vesicle defining the supramolecular complex that makes the.
