SCA-UA 1 Lecture Notes - Lecture 13: Sciatic Nerve, Cytoplasm, Neuroglia
27 Mar 2016
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Lecture 13: microtubules, intermediate filaments and motors: kinesins and dyneins. Slide 2: the core components of cytoskeleton. Actin: made of globular monomers making polymers fibrous. Microtubules: monomers are different but also globular and make tubules that are thicker than filaments. Intermediate filaments: there exact distribution depends on the cell type ad is not uniform. Image: showing that monomers are bound to atp forming rigid gels, networks and linear bundles or contribute to branching. Regulation:assembly is highly regulated at the level of nucleation depending on ros-gtpases, regulation level of availability of actin monomers which controls rate of polymerization, regulation of capping and depolymerization. Important point: the assembly can start from many different places in the cell: Nucleation initiation depending on signaling and location of. Gtpases to activate formins means it can start anywhere. Cytoskeleton is highly dynamic markedly polarized: actin filaments serve as tracks for myosin which coupled are involved in motive machinery. Key differences and similarities between microfilaments and microtubules.
