HC 100 Lecture Notes - Lecture 6: Ventricular Fibrillation, Bidomain Model, Ventricular Tachycardia

• School: Oakland University
• Department: Honors College
• Course: HC 100
• Professor: Greame Harper

Document Summary

Cardiovascular disease is an underlying cause of death accounting for more than one third of all deaths in the united states. In the united states over 300,000 people die each year of sudden cardiac death with most of those deaths associated with ventricular fibrillation. Charged his heart and threw himself into fibrillation and died. Goal:figure out how defibrillation works with a mathematical model. Inside cell motion without ever going into extracellular space. Extracellular space travel without ever going inside cell. Bidomain model: intracellular extracellular connected by the membrane. Hypothesis: unequal anisotropy ratios is important during stimulation of cardiac tissue. Test of hypothesis: perform computer simulation using bidomain model. Prediction: virtual anodes located on each side of cathode during unipolar stimulation of cardiac tissue. Test prediction: measure transmembrane potential in cardiac tissue during stimulation. Nih national institutes of health bethesda , maryland.