BIOS 4630 Lecture Notes - Lecture 1: Relative Permittivity, Cholesterol, Protein Folding
11 Jan 2017
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Document Summary
Losing a protein function for example in cystic fibrosis. Mutations in the cystic fibrosis membrane receptor lead to loss in function of that protein: che(cid:373)i(cid:272)al r(cid:454)(cid:374)s (cid:374)e(cid:272)essar(cid:455) for life . Historical perspective: wohler 1828: synthesized urea in lab, without requiring a kidney or an animal, Ii. either man or dog: this was really the origin of biochemistry, biochemical pathway that leads to the synthesis of urea. Biochemical literature: journals devoted to all aspects of biochemistry, proteins, lipid structure etc, allows us to understand biodiversity of biochemistry. Free radical biology and medicine: reactive oxygen species (ros): naturally produced in a variety of different metabolic reactions. Some of these ros are detrimental, some can do damage to cells or proteins or dna or lipids. But there is a certain balance between beneficial ros such as signaling and detrimental ros leading to cell damage and cell death: cv, pulmonary, neurodegenerative diseases (atherosclerosis, alzheimers), aging biology: oxidative stress, reproduction (e. g. fertility): contraception.
