BIO 203 Lecture Notes - Lecture 14: Red Blood Cell, Erythropoietin, Megakaryocyte

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Published on 16 Apr 2019
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Life cycle of red blood cells
Produced in the red bone marrow
Live about 120 days
Undergo phagocytosis in the liver and spleen
Hemoglobin in degraded into its protein component (globin) and heme
component
The iron form the heme is sent to the bone marrow for recycling
The remaining portions of heme are degraded to bilirubin, which the liver
releases in bile
Production of red blood cells
Regulated by a negative feedback mechanism
Production typically matches destruction
In the case of blood loss, the rate of RBC production is increased
Kidney cells sense reduced oxygen and produce the hormone
erythropoietin
Erythropoietin stimulates the red bone marrow to produce more
RBCs
The increased oxygen-carrying capacity of the blood inhibits
production of erythropoietin
White blood cells
White blood cells and defense against disease
Also called leukocytes
Have a nucleus
One type is produced in lymph nodes and other lymphoid tissue
General functions
Remove wastes, toxins, and damaged and abnormal cells
Help defend the body against disease
Can leave the circulatory system and move to the site of infection
or tissue damage
Some are capable of phagocytosis
Two groups are based on the presence or absence of granules in the cytoplasm
Granulocytes: possess granules
Classified based on how they stain
Neutrophils do not stain
Basophils stain purple
Eosinophils stain pink
Agranulocytes: lack visible granules
Monocytes
Lymphocytes
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