BIOL 039 Lecture Notes - Lecture 32: Alternative Splicing, Growth Factor, Nuclear Membrane
Document Summary
Because of the way how eukaryotic genome is structured (chromosomes with several levels of chromatin packaging) and compartmentalized (separated from cytoplasm with the nuclear envelope), the processes that regulate gene expression in eukaryotes are very diverse. Expression of a gene in the eukaryotic cell includes multiple steps, each of which could in principle be a regulatory point. 1. transcriptional control - when and where the gene is activated. 2. rna processing control - determines the splicing pattern. 3. rna transport control - determines which transcript to export. 4. translational control - determines which rna will be translated. 5. degradation control - selectively targets rnas for degradation. 6. protein activity control - selectively activates/inactivates protein. Alternative splicing of rna (mammalian troponin-t gene) molecules. Phenomenon of splicing an rna transcript in different ways is called alternative splicing. Alternative splicing allows for a single gene to encode several polypeptides.
