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Lecture 36

AN SC 431W Lecture 36: Lecture 36
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Spring 2017

Department
Animal Science
Course Code
AN SC 431W
Professor
Ott Troy
Lecture
36

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REPRODUCTIVE IMMUNOLOGY QUIZ
1. Chemokine: hormone that attracts immune cells to site of infection
a. Chemical mediator secreted from one tissue that acts on another tissue to change
function
2. Broad specificity is not a component of the adaptive immune response
a. Adaptive immunity has a very narrow memory
3. Receptors undergo rearrangement is not component of the innate immune response
a. Receptors are encoded by germline, no rearrangement
4. Estrogen induces production of defensins by the uterine mucosa
a. Estrogen increases during estrus (anticipation of mating) to defend against
microbes during copulation
5. Dr. Medawar is credited with starting the discipline of reproductive immunology
6. Medawar’s theories for why conceptus is not rejected by mother’s immune system:
a. Anatomical separation of fetus from mother (placenta)
b. The antigenic immaturity of the fetus allows it to “hide” and not produce antigens
c. The immunological indolence/inertness of the mother, suppresses her immune
system
7. Plasma cell produces the largest amount of immunoglobulins (Igs) after antigen
stimulation
8. Complement forms membrane attack complexes and punches holes in membranes
9. B cells and T cells are part of the adaptive immune system
10. Neutrophils are primarily responsible for phagocytosis
a. Phagocytic cells: macrophage, neutrophil, dendritic cells
b. AKA “antigen presenting cells” to stimulate other immune cells
THE PREGNANCY PARADIGM
A. The conceptus is semi-allograft (half DNA is from different genotype than mother). How
is pregnancy possible?
a. Conceptus must evade immune response of dam
b. Dam must regulate her immune system
c. Conceptus must regulate the dam’s immune system
B. Major Histocompatibility Complexes (MHC)
a. Class I MHC in all nucleated cells
b. Class II MHC in antigen presenting cells
i. Display antigens from pathogen to activate T helper cells
C. The peculiar horse conceptus
a. Invasive cells on placentaendometrial cups that produce eCG
i. AKA pregnant mare serum gonadotropin (PMSG)
ii. Form at 35-40 days in pregnancy, disappear around 120 days
b. Maternal immune cells come in and respond to endometrial cupsdestroy
c. eCG acts like LHsupport existing CL, and stimulate mare to ovulate and
produce accessory CLs
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REPRODUCTIVE IMMUNOLOGY QUIZ 1. Chemokine: hormone that attracts immune cells to site of infection a. Chemical mediator secreted from one tissue that acts on another tissue to change function 2. Broad specificity is not a component of the adaptive immune response a. Adaptive immunity has a very narrow memory 3. Receptors undergo rearrangement is not component of the innate immune response a. Receptors are encoded by germline, no rearrangement 4. Estrogen induces production of defensins by the uterine mucosa a. Estrogen increases during estrus (anticipation of mating) to defend against microbes during copulation 5. Dr. Medawar is credited with starting the discipline of reproductive immunology 6. Medawar’s theories for why conceptus is not rejected by mother’s immune system: 1.a. Anatomical separation of fetus from mother (placenta) 1.b. The antigenic immaturity of the fetus allows it to “hide” and not produce antigens 1.c. The immunological indolence/inertness of the mother, suppresses her immune system 7. Plasma cell produces the largest amount of immunoglobulins (Igs) after antigen stimulation 8. Complement forms membrane attack complexes and pu
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