B M B 211 Lecture Notes - Lecture 11: Atp Synthase, Oxidative Phosphorylation, Intermembrane Space

• School: PSU
• Department: Biochemistry and Molecular Biology
• Course: B M B 211
• Professor: Giebink Heather

Document Summary

Oxidative phosphorylation: the process that conserves the energy of the electron transport chain by phosphorylation of adp to atp. The imbalance of protons represents a source of free energy called protonmotive force that can drive the activity of atp synthase. The imbalance of protons is a nonequilibrium state so there is an association free energy or a force that would restore the system to equilibrium. One proton moving from the intermembrane space back to the mat(cid:396)i(cid:454) (cid:396)esults i(cid:374) a g= -20kj/mol. Fo(cid:396) ea(cid:272)h pai(cid:396) of ele(cid:272)t(cid:396)o(cid:374)s t(cid:396)a(cid:374)sfe(cid:396)(cid:396)ed f(cid:396)o(cid:373) nadh to o(cid:1031) i(cid:374) the ele(cid:272)t(cid:396)o(cid:374) t(cid:396)a(cid:374)spo(cid:396)t (cid:272)hai(cid:374), (cid:1005)(cid:1004) p(cid:396)oto(cid:374)s a(cid:396)e pu(cid:373)ped f(cid:396)o(cid:373) the (cid:373)at(cid:396)i(cid:454) to the i(cid:374)te(cid:396)(cid:373)e(cid:373)(cid:271)(cid:396)a(cid:374)e spa(cid:272)e (cid:894) g= -200kj/mol) The protein that used the electrochemical proton gradient to phosphorylate adp is atp synthase (harnesses energy) The two subunits link the exergonic h transport to the endergonic atp synthesis. The inner membranes of mitochondria are full of atp synthases and complexes.