B M B 211 Lecture Notes - Lecture 14: Acetyl-Coa, Carnitine, Intermembrane Space

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Fatty acids are stored as trigl(cid:455)(cid:272)erides a(cid:374)d are the (cid:271)od(cid:455)(cid:859)s lo(cid:374)g ter(cid:373) e(cid:374)erg(cid:455) sour(cid:272)e. Fatty acids release more energy than carbohydrates (38 kj/g vs 16 kj/g) A 154 lb human with about 33 lb of body fat (21% body weight) has fuel reserve for 2 months. When energy reserves are low, the body fat stores are mobilized in a process called lipolysis. Hormones activate hormone-sensitive lipase, an enzyme which hydrolyzes triglycerides into glycerol and free fatty acids. Mobilized fatty acids travel through the bloodstream bound to albumin, a transport protein. Fatty acids travel to the liver and muscle cells. Heart cells prefer to burn fatty acids over carbohydrates. Brain and red blood cells cannot use fatty acids at all. Once inside the cell, fatty acid-binding proteins transport fatty acids to the organelles. In the mitochondria, fatty acids will be degraded to form acetyl-coa in a process called -oxidation.

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