B M B 211 Lecture Notes - Lecture 15: Covalent Bond, Cortisol, Membrane Transport Protein

• School: PSU
• Department: Biochemistry and Molecular Biology
• Course: B M B 211
• Professor: Giebink Heather

Document Summary

After a meal or when energy reserves are high, the body will activate fat storage. When glycogen stores are full, body converts to fatty acid synthesis. E(cid:454)(cid:272)ess a(cid:272)et(cid:455)l coa does(cid:374)"t go th(cid:396)ough (cid:272)it(cid:396)i(cid:272) a(cid:272)id (cid:272)(cid:455)(cid:272)le. The liver is the primary site for fatty acid synthesis, which occurs when the diet is low in fat and/or high in carbohydrates. The body needs fat and adipose tissues can also make fatty acids. (cid:455)(cid:374)thesis of pal(cid:373)iti(cid:272) a(cid:272)id (cid:894)(cid:1005)(cid:1010):(cid:1004)(cid:895) (cid:396)e(cid:395)ui(cid:396)es (cid:1012) a(cid:272)et(cid:455)l coa (cid:373)ole(cid:272)ules, (cid:1005)4 nadph a(cid:374)d (cid:1011) atp (cid:894)+ g so takes a lot of energy) Problem: acetyl-coa that we need for fatty acid synthesis is in the mitochondrial matrix, we need it to be in the cytoplasm for fatty acid synthesis. The transport of acetyl-coa involves citrate which does have a transport protein. Oxaloacetate goes to citrate which can cross the membrane via a transport protein; it is then regenerated back into oxaloacetate.