BIOL 222 Lecture 21: Biol 222 - Lecture 21 - Polyploidy

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Biol 222 lecture 21 polyploidy and aneuploidy. Aneuploidy the chromosome number differs from the wild type by part of a chromosome set. Caused by nondisjunction n the haploid number of chromosomes in an organism. Nullisomy the loss of both members of homologous pair of chromosomes (2n-2) Monosomy the loss of one member of a homologous pair of chromosomes (2n-1) Trisomy the gain of one chromosome (2n+1) Tetrasomy the gain of two homologous chromosomes (2n +2) Double monosomy - the loss of two nonhomologous chromosomes (2n -1 -1) Double trisomy the gain of two nonhomologous chromosomes (2n+1+1) Nondisjunction the failure of homologous chromosomes to separate during or failure of sister chromatids to separate during meiosis ii. ~30% of all human conceptions spontaneously abort (miscarry) ~50% of spontaneous abortions have a major chromosome abnormality (usually aneuploidy) ~2% of human fetuses with a chromosome defect survive to birth. This is the only human monosomic condition that survives.

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