BIOL 222 Lecture Notes - Lecture 19: Transcription Factor Ii D, Tata-Binding Protein, Tata Box
Document Summary
Biol 222 lecture 19 eukaryotic gene regulation. Many regulatory proteins are typically required to activate transcription. Gene expression is restricted by chromatin structure (nucleosome position) Tata box tata binding protein (tbp) binds to the tata box. Tbp is part of the transcription factor ii d (tfiid) complex. Core promoter - portion of the proximal promoter that contains the transcription start sites. Regulatory promoter - capable of increasing or decreasing the expression of the genes. Not all genes have the tata box, but highly expressed ones do. Cat box, gc box, oct box (specific dna sequences) Typically extend 100 to 300 base pairs upstream of the core promoter. Tata, cat, gc, and oct boxes are recognized by the general transcription factors (nusa and. The other boxes are part of the regulatory promoter. Enhancers greatly increase transcription initiation at promoters (activation) Activator proteins bind to enhancer sequences and assist rnap ii binding. Silencers greatly reduce transcription initiation at promoters (repression)
