KINES 456 Lecture Notes - Lecture 10: Adipokine, Adiponectin, Adipose Tissue

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14 Sep 2016
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Endocrine theory: adipose tissue assumed to be an organ of energy storage, however, it was found that adipose tissue releases cytokines (adipokines, obese people have more adipose tissue; release more adipokines. Influence appetite, insulin sensitivity, angiogenesis, blood pressure (hypertension), stroke and cvd risk. Adipokines: in obese individuals, the adipose tissue can be considered the largest organ in the body. Leads to incredibly large secretion levels of adipokines. Easy access to systemic circulation (good blood supply: il-6, tnf- , adiponectin (most important) Adiponectin downregulates macrophage activity, decreases inflammation: crp (c-reactive protein) Not necessarily relevant to atherosclerosis development: igf, tgf-b, cortisol. White blood cells won"t stick; can"t move into subendothelial space (ses) and therefore will not become a foam cell. Il-6 and tnf- inhibit adiponectin release: il-6 leads to decreased appetite. Increased fatty acid and cholesterol synthesis in the liver. Il-6 is the reason you don"t want to eat when you get sick: tnf and ffa lead to decreased insulin sensitivity.

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