Week 3 - Proteins (Ch. 3), Nucleic Acids and RNA (Ch. 4), How Genes Work (Ch. 16)

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University of Pittsburgh
Biological Sciences
BIOSC 0150
Laurel Roberts

Week 3 Monday, September 9, 2013 6:00 PM Concepts Covered This Week: Protein Structure and Function (Chapter 3) Nucleic Acids and RNA (Chapter 4) How Genes Work (Chapter 16) You should be able to • Name the monomer • Draw a monomer • Name and correctlyplace the “external” bonds • Explain the significance of the types discussed in class • Explain the relationship between proteins and nucleic acids • Draw semi-conservativereplication and explain its significance Nucleic Acids • Nucleotide ○ Sugar + Phosphate + Base • Nitrogenous base • PentoseSugar • A, T, G, C, U • Phosphodiesterbond Pyrimidinesand Purines • Cytosine • Uracil • Uracil • Thymine "External Bonds" • Primary:Phosphodiester ○ Polar covalent bond ○ Dehydration synthesis • Secondary: Hydrogen RNA • Single stranded or double • Messenger • Catalyst Becoming Double-Stranded (ComplementaryBase Pairing) • Why is DNA the genetic material for multi-cellular organisms and not RNA? ○ More stable; will survive wound-up in the nucleus ○ Complementarybase pairing: even if damaged, can fill in from the other side DNA Replication • Semi-conservativereplication: Half old, Half new • A ↔ T •
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