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BIOSC 0715 (21)
Lecture 20

BIOSC 0715 Lecture 20: Lecture 18c

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University of Pittsburgh
Biological Sciences
BIOSC 0715
Karen Curto

Biology Lecture 16c 12616 CRISPRCas 9 a primitive and selective immune response Clustered regularly interspaced short palindromic repeats Repeats Nucleotide repeats in bacterial chromosome Spacers also called crRNA Viral genetic material put into bacterial chromosome Cas9 An endonuclease TracrRNA (guide RNA) crRNA Recruits Cas9 and matches up to viral gene Bacteria recognizes viral DNA as nonself and put it into CRSIPR, which serves as a memory of previous infections On first exposure to virus, Cas complex (Cas1, Cas2, Csn2) cut the viral DNA and form it into a spacer On second exposure to virus, TracrRNA and Cas9 are translated to scan the viral DNA to find the sequence RNase III is a participant in assembling guide RNA and adding with viral DNA In bacteria, mission accomplished when viral DNA has been destroyed no infection Recitation 12b 1. True or false? On the second injury at the same location on a patients arm, the response by the innate immune system will be faster and stronger. Explain False acquired immune system would be faster and stronger, innate will stay the same 2. Two types of glycoproteins on T cells CD4 T helper; and CD8 T cytotoxic 3. Carries both antiA and antiB antibodies Type O 4. What organelle may be especially enlarged in an activated B memory cell and why? R.E.R. proteins are synthesized 5. A couple is expecting their fourth child. The father is Rh+ and the mother is Rh. Should they be worried?
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