BIOSC 1000 Lecture Notes - Lecture 4: Hemoglobin, Elution, Diethylethanolamine
1 Feb 2017
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Document Summary
All amino acids have the same basic structure. The central carbon is chiral four di erent substituents on the carbon (tetrahedral c) chiral molecules have non-superimposable mirror images. Stereoisomers have the same molecular formula but di erent atom con gurations (spatial arrangements) L-amino acids are what you nd in proteins. Amino acids contain at least two ionizable groups. Amino acids exist as zwitterions at a neutral ph. The chemical characteristics (functionally) of an amino acid are determined by its side chain (r group) The pka values of ionizable groups can be a ected by neighboring chemical groups. Histidine ionizes - quickly accepts and donates protons pka ~6 bu ering region 5-7 (around physiological ph) The titration curve of his shows three possible ionizable steps. Cys can react to form disul de bonds - 2 cysteines form a cystine disul de bond = covalent bond can break this bond via reduction.
