BIOSC 1250 Lecture Notes - Lecture 8: Skeletal Muscle, Myocyte, Myofibril

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23 Nov 2017
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Muscle is specialized for contraction: movement within & manipulation of external environment, movement of contents through tubes (hollow organs) in the body, exchange of substances b/t internal & external environments. Most prominent muscle (~80%) (cid:862) t(cid:396)iated (cid:373)us(cid:272)le(cid:863) typi(cid:272)ally (cid:396)efe(cid:396)s to skeletal (cid:373)us(cid:272)le. Mus(cid:272)le is(cid:374)"t (cid:395)uite (cid:373)ade of (cid:272)ells it"s (cid:373)ade of muscle fibers, held together by connective tissue. Muscle muscle fibers myofibrils ( means made of) Innervates autonomic ns (lines gi tract, blood vessels, etc. : t-tubules: channels on sarcolemma that into & through the muscle; have ecf inside. Sarcomere = smallest unit of myofibril, bounded by. Thin & thick filaments slide past each other. (z lines get pulled toward each other) Sarcomere shortens during contraction, as filaments slide past each other. Titin: large & important structural protein in the sarcomere; titin extension is a passive process of the muscle going back to the relaxed state after contraction. Also can sense degree of stretch & regulate actin-myosin interactions.

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