BIOSC 0100 Lecture Notes - Lecture 10: Fluid Mosaic Model, Lipid Bilayer, Electrochemical Gradient

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Early models of the cell membrane suggested that the phospholipid bilayer was sandwiched between proteins. Singer and nicolson challenged the sandwich model and proposed that amphipathic proteins could span the membrane. Fluid mosaic model (1972) current model of cell membrane structure. Embedded within the hydrophobic interior of lipid bilayers. Amphipathic with a hydrophobic region that may cross the entire membrane or extend only part way into the bilayer. If the integral proteins span the entire membrane and have hydrophilic inside and outside the cell is called a transmembrane protein. Can be isolated from membranes with detergents (amphipathic molecules) Proteins bind to the membrane without passing into the membrane. Found only on one side of the membrane. Non-covalent interactions often attached to integral membrane proteins. Act as tunnels for ions or small molecules to cross a membrane. Highly selective allow only a particular type of ion or molecule to pass through.

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