NROSCI 0081 Lecture Notes - Lecture 14: Gastric Lavage, Adme, Chewing Tobacco
19 Feb 2018
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Document Summary
Intramuscular (im): injected into muscle: depo-provera shot, muscle has good blood supply, faster onset and predictable absorption over time but slower than iv, subcutaneous (sc): injected just below the skin. Insulin: absorption is dependent on blood flow, slower than im. Inhalation: smoking or vaporous inhalation, very rapid absorption, lungs have large surface area rich in blood vessels, blood flows directly to brain, disadvantages, health risks associated with inhaled material, highly addictive. Intranasal: applied to mucous membranes of nose (snorting, cocaine, sublingual, applied under the tongue, lsd, transdermal, applied to skin, hormones, buccal. In the mouth, absorbed through the cheek: chewing tobacco. Getting the drug from where it is administered to the blood circulation. There are many barriers between the site of administration and the bloodstream. Barriers are generally membranes that drugs must pass through before entering the bloodstream. Concentration: chemicals move from areas of high concentration to areas of low concentration.
