NROSCI 0081 Lecture Notes - Lecture 20: Harrison Narcotics Tax Act, Crack Cocaine, Stereotypy
Document Summary
Drugs (cid:449)ith (cid:862)(cid:272)ai(cid:374)e(cid:863) i(cid:374) the (cid:374)a(cid:373)e (cid:271)lo(cid:272)k na+ channels (can block pain) The harrison narcotics act (1914) prohibited non-medical use of cocaine. Trafficking of cheap smokeable cocaine in us. U go(cid:448)"t (cid:373)a(cid:455) ha(cid:448)e helped fu(cid:374)d co(cid:374)tra re(cid:271)els & (cid:272)oke traffi(cid:272)ki(cid:374)g. Cocaine toxicity: loss of consciousness, seizures, damage to nasal membranes (snorting, liver damage with chronic use, strokes, neuronal death. Stereotypy: involuntary repetitive movements which can be caused by stimulant abuse. E. g. clenching jaw, fidgeting with hands, scratching same place can be caused by cocaine or amphetamines. Pharmacotherapy for cocaine treat depression with anti-depressants cocaine vaccine immune system trained to recognize cocaine in blood stream, then antibodies attach to cocaine, and cannot cross bbb. Amphetamine class of drugs: methamphetamine, ritalin, mdma, ecstasy, molly, (cid:862)(cid:271)ath salts(cid:863) Ephedrine: introduced as asthma treatment in 1880s (dilates airways in the lungs and makes breathing easier) in search for synthetic substitute of ephedrine, amphetamine & meth were produced.
