NROSCI 0081 Lecture Notes - Lecture 25: Dextromethorphan, Hypoventilation, Catatonia
Document Summary
Synthetic drug initially used as an anesthetic: was(cid:374)"t effe(cid:272)ti(cid:448)e (cid:271)e(cid:272)ause , patie(cid:374)ts did(cid:374)"t respo(cid:374)d to pai(cid:374) (cid:271)ut did (cid:374)ot go u(cid:374)(cid:272)o(cid:374)s(cid:272)ious, trance-like catatonia (immobile), hallucinations, violence, no respiratory depression and high ti. Adopted by vietnam war protestors: never as popular as heroin, weed, and cocaine. Side effects: hallucinations, detachment from reality, confusion, feelings of power, paranoia, psychotic symptoms, self-injury. Inhalation: sometimes in liquid form and can spray it on weed or nicotine, many people accidentally experience pcp (contaminated weed, often very contaminated (10-30% of pcp) Causes detachment, reduced sensation, altered perception dissociative: (cid:862)k-hole(cid:863) Intranasal as club drug: acts on glutamate receptors, noncompetitive antagonist at nmda receptor, reduces glutamate activity, removal of excitatory force. Low doses being used to treat depression: sub-anesthetic and sub-psychotomimetic. Ketamine restores the same behavior in a susceptible mouse to a resilient mouse (social interaction) Ketamine increases social interaction in mice susceptible to depression-like behavior.
