NROSCI 0081 Lecture Notes - Lecture 29: Basal Ganglia, Nabiximols, Xerostomia
20 Apr 2018
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The flowering tops of the plant (buds) Cannabis indica: cultivated for medical and recreational use. Cannabis ruderalis: native to russia and eastern europe. Most widely used illegal drug in the us. 1841 introduced to western medicine: anti-convulsant, appetite stimulant. 1870 listed in the us parmacopoeia (pharmacy book) as medicine for various ailments. 1916 government starts to cut down on cannabis. 1920s references to mexican-a(cid:373)erica(cid:374) a(cid:374)d africa(cid:374) a(cid:373)erica(cid:374) use of (cid:862)(cid:373)arijua(cid:374)a(cid:863) li(cid:374)ked to violent acts. Prohibition increased the use of cannabis for recreational use. Marijuana tax act of 1937: excessively tax the grower, distributor, seller, and buyer. Reefer madness was meant to fuel the cannabis panic (1936: permanent brain damage. Incited violent behavior: linked to undesirable immigrants. 70s increased regulation and restrictions: comprehensive drug abuse prevention and control act, made marijuana a schedule i drug. Lipophilic compounds (fat soluble) stored in your fat cells = depot binding. Cannabinoid (cbd: not psychoactive but medically relevant, anti-anxiety, anti-psychotic, anti-inflammatory, anti-nausea.
