NROSCI 1030 Lecture Notes - Lecture 11: Hypokinesia, Intention Tremor, Mental Disorder
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Background: more of a neurological disorder than a psychiatric disorder, a (cid:374)u(cid:373)(cid:271)er of pro(cid:373)i(cid:374)e(cid:374)t (cid:272)ases of parki(cid:374)so(cid:374)"s disease, mohammad ali, michael j. Four cardinal signs: resting tremor, when you move the shaking disappears, 3-5 hz. Just (cid:271)e(cid:272)ause they are(cid:374)"t (cid:373)o(cid:448)i(cid:374)g does(cid:374)"t (cid:373)ea(cid:374) their (cid:373)us(cid:272)les are(cid:374)"t (cid:272)o(cid:374)tra(cid:272)ti(cid:374)g: they are actually contracting all the time, coqwheel rigidity, paradoxical kinesia, posture, hunched hard time maintaining an upright posture. If you push someone with parki(cid:374)so(cid:374)"s, they just fall (cid:271)a(cid:272)k(cid:449)ards. Autonomic signs: hyperthermia elevated body temperature, edema, salivation, sweating. In 1957 a. carlsson discovered the problem to be dopamine as a transmitter. In 1960 hor(cid:374)ykie(cid:449)(cid:272)a fou(cid:374)d a(cid:374) (cid:1012)(cid:1004)% i(cid:374)(cid:272)rease of dopa(cid:373)i(cid:374)e i(cid:374) the straitu(cid:373) of parki(cid:374)so(cid:374)"s. Etiology: not very understood, very low concordance in families, tends to be higher in developed countries not sure if this is just because developed countries. In 1960, they started to see an increase in parkinsons incidences: cycod toxin kills dopaminergic neurons excitation bmaa.
