ANSC 23000 Lecture Notes - Lecture 2: Thrombocytopenia, Antibody, Aplasia

• School: Purdue University
• Department: Animal Sciences
• Course: ANSC 23000
• Professor: Allrich Rod

Document Summary

Very small, fragments of bigger mother cells, anuclear. Function: form the initial hemostatic (hemo: blood static: stop) plug whenever hemorrhage occurs: source of phospholipid which is needed in coagulation factors to form a fibrin clot. Produced: in the bone marrow from megakaryocytes, influenced by thrombopoietin (protein the stimulates and diffs. Megakaryotes: process: invagination, turned inside out, of the megakaryocyte cell membrane and formation of cytoplasmic channels and islands. The cytoplasmic islands produce platelets by fragmentation from the megakaryocyte. Platelet disorders: quantitative (thrombocytopenia or thrombocytosis) or qualitative (thrombocytopathy: thrombocytopenia: one of the most common bleeding disorders in animals, deficiency of platelets in blood. Increased production by bone marrow or the consumption, destruction, or sequestration of platelets causes it. Von willebrand disease: defect in platelet adhesion to the endothelium (single layer of tissue formed on lining inside organs) Irreversible inhibition of thromboxane: caused by aspirin ad(cid:373)i(cid:374)istratio(cid:374), ca(cid:374)"t i(cid:374)duce platelet aggregatio(cid:374)