NUR 424 Lecture Notes - Lecture 12: Bone Marrow Examination, Hematopoietic Stem Cell, Tumors Of The Hematopoietic And Lymphoid Tissues
Document Summary
Chapter 34: management of patients with hematologic neoplasms, pp. Hematologic: hematopoiesis: complex process of the formation and maturation of blood cells, rapid, continuous turnover of blood cells, hematologic malignancies are often classified by the cells involved, leukemia, myelodysplastic syndrome, lymphoma, thrombocytopenia, myeloma. Cll chronic lymphocytic leukemia: myeloid stem cells that myeloid blood cells. Acute myeloid leukemia: results from a defect in the hematopoietic stem cell that differentiates into the myeloid cells, monocytes, granulocytes, erythrocytes and platelets, any age group can be affected, frequently occurs before age 55. If remission is achieved, next step is bone marrow transplant: complications, bleeding and infections. Chronic myeloid leukemia: arises from a mutation in the myeloid stem cell, 90-95% patients with cml have an abnormal chromosome called the. Ph chromosome is the result of a translocation of a cancer-causing gene (oncogene) called the bcr-abl gene: the bcr-abl oncogene gives stem cells instructions to make a dysfunctional protein called bcr-abl tyrosine kinase.
