NUR 426 Lecture Notes - Lecture 1: Overactive Bladder, Nicotinic Acetylcholine Receptor, Bronchodilator

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13 Sep 2017
Anticholinergic Drugs
The sympathetic nervous system mediates the fight or flight response: SNS axons react with
adrenergic receptors
The parasympathetic nervous system mediates the rest and digest response: PNS axons react
with the cholinergic receptors
Autonomic disorders
Less swearing heat intolerance (at risk for heat stroke)
Pupils may not adjust to changing light conditions (accommodation)
Dry mouth
Dizziness or light-headaches due to orthostatic hypotension
Gastroparesis (no motility), nausea after eating
Urinary incontinence or urinary retention
Constipation or fecal incontinence
Difficulty maintain an erection
Autonomic disreflexia spinal cord injuries
Fight or flight
Sweaty palms, hair stands
Neurotransmitter: norepinephrine
Effects on body
- Eyes dilate (mydrias)
- Heart rate increases, BP increases, increased contractility
- Increased need for CO
- Bronchioles dilate
- Liver releases glucose (diabetics under stress have increased glucose)
- Bladder sphincters constrict
- Muscles increased strength
Adrenergic receptors
- Alpha 1&2
- Beta 1&2
Rest and digest
Neurotransmitter: acetylcholine
Effects on body
- Pupils constrict, accommodate
- Increased sweat (cool down)
- Increased saliva
- Decreased HR, bP, contractility
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