NUR 426 Lecture Notes - Lecture 7: Hepatotoxicity, Folinic Acid, Paclitaxel

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25 Oct 2017
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Platinum agents: cisplatin: cell cycle specific act on a specific part of the cell cycle. Hormonal agents tamoxifen: targeted therapies - Differences: act on different parts of cell cycle, act on all rapidly reproducing cells, act on cells that express certain genes or receptors, different acute toxicities (including emetogenic potential, different long term toxicities. Chemotherapy: breast cancer: ac = adriamycin, cyclophosphamide, caf = adriamycin, cyclophosphamide, fluorouracil, cmf = cyclophosphamide, methotrexate, fluorouracil (hormone receptor +): +/- tamoxifen (human epidermal growth factor receptor 2 positive) (her2): +/- trastuzumab / vinorelbine or paclitaxel. Combination chemotherapy: act in different phase of cell cycle, reduce resistance, reduce dose of individual agent, reduce toxic effects to healthy cells. Rapidly growing cells: cancer cells, hair, nails, skin, mucosal membrane. Contraindications/cautions: pregnancy or lactation, renal or hepatic failure, blood dyscrasias, gastric ulcers. Dysrhythmia; delayed dilated cardiomyopathy, heart failure; myelosuppression and cardiotoxicity are dose related; monitor ekg.

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