NUR 426 Lecture Notes - Lecture 7: Hepatotoxicity, Folinic Acid, Paclitaxel

33 views5 pages
25 Oct 2017
Department
Course
Professor
Chemotherapy Agents
Vocabulary
Extravasation serious problem with chemotherapy agents
Vesicant means to blister (causes blisters)
Alopecia hair loss
Absolute neutrophil count (ANC) what the exact number of neutrophils (should be over 1500)
Emetogenic nausea causing
Tumor lysis syndrome (TLS) cause body to go into over drive and kill cells
Categories
Cell Cycle nonspecific
- Alkylating agents: Cyclophosphamide
- Platinum agents: Cisplatin
Cell cycle specific act on a specific part of the cell cycle
- Antimetabolites methotrexate, 5-Flourouracil (5-FU)
Used a lot in brain cancer
5FU used in colon cancer
- Antitumor antibiotics doxorubicin
Side effect is red urine
- Antimitotic Vinca alkaloids (vincristine), paclitaxel
- Hormonal agents tamoxifen
Targeted therapies -
- Protein tyrosine Kinase inhibitors: Imatinib
- Epidermal growth factor inhibitors
- Monoclonal antibodies
- Others
Differences
Act on different parts of cell cycle
Act on all rapidly reproducing cells
Act on cells that express certain genes or receptors
Different acute toxicities (including emetogenic potential)
Different long term toxicities
Chemotherapy: Breast Cancer
AC = Adriamycin, cyclophosphamide
CAF = Adriamycin, cyclophosphamide, fluorouracil
CMF = cyclophosphamide, methotrexate, fluorouracil
(hormone receptor +): +/- tamoxifen
(human epidermal growth factor receptor 2 positive) (HER2): +/- trastuzumab / Vinorelbine or
paclitaxel
find more resources at oneclass.com
find more resources at oneclass.com
Unlock document

This preview shows pages 1-2 of the document.
Unlock all 5 pages and 3 million more documents.

Already have an account? Log in
Combination Chemotherapy
Act in different phase of cell cycle
Reduce resistance
Reduce dose of individual agent
Increases effectiveness
Reduce toxic effects to healthy cells
Rapidly growing cells
Cancer cells
Hair
Nails
Skin
Mucosal membrane
Contraindications/Cautions
Pregnancy or lactation
Renal or hepatic failure
Blood dyscrasias
Gastric ulcers
Selected Toxicities
Doxorubicin cardiotoxicity
- Dysrhythmia; delayed dilated cardiomyopathy, heart failure; myelosuppression and
cardiotoxicity are dose related; monitor EKG
- Life time cumulative dose 550mg/m2
- Base line echo and EKG; calcium channel blockers may increase cardiotoxicity;
phenobarbital may decrease metabolism
Cyclophosphamide hemorrhagic cystitis
- Stay hydrated
Cisplatin renal toxicity, hearing loss
5-FU GI toxicity (mucositis, diarrheal), photosensitivity
- Check oral mucosa daily; teach mouth care; sunscreen
Vinca Alkaloids neurotoxicity (central and peripheral)
- Ataxia, nystagmus
Taxanes peripheral neuropathy, cardiac effects
- Weakness, paresthesia, numbness; decreased reflexes
Methotrexate mucositis, hyperuricemia
Targeted therapies
- Infusion reactions
- Hypersensitivity
- Flu-like symptoms
find more resources at oneclass.com
find more resources at oneclass.com
Unlock document

This preview shows pages 1-2 of the document.
Unlock all 5 pages and 3 million more documents.

Already have an account? Log in

Get OneClass Notes+

Unlimited access to class notes and textbook notes.

YearlyBest Value
75% OFF
$8 USD/m
Monthly
$30 USD/m
You will be charged $96 USD upfront and auto renewed at the end of each cycle. You may cancel anytime under Payment Settings. For more information, see our Terms and Privacy.
Payments are encrypted using 256-bit SSL. Powered by Stripe.