01:119:115 Lecture Notes - Reverse Transcriptase, Cell Membrane, Immunoglobulin A

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All cells involved in specific immunity some from the bone marrow (fig 45-5: nk cells are specialized lymphocytes: active against virally- infected and cancer cells. Release perforins, and then granzymes with cytokines induce cellular apoptosis. First antibody produced in an immune response; disappears within two weeks (75% of circulating antibodies) providing longer term immunity; igm and igg are usually measured together: Present in mucus, tears, saliva, and breast milk - secreted into respiratory, digestive, and urinary and reproductive tracts. In plasma membrane of immature b cells and also secreted; can cause hemolytic anemia in babies. Produced in response to pollen (allergen), binds to mast cells that then release histamine attracting neutrophils - allergic reaction includes inflammation. Memory cells are only produced during active immunity (table 45-1) Monoclonal: polyclonal: when an animal is challenged with an antigen, it responds by making abs with many different specificities directed against epitopes contained in complex antigen, monoclonal: immunization is highly specific.

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