01:146:356 Lecture 24: SYS 24

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System physiology notes: renal system- gfr starling forces (day 2) Clearance of gfr and the starling forces associated. Younger person should be less than older person. Older would be more because the nephrons are less active/ functional, so there is not as much absorption back into body, therefore more is release/excreted. Collective glomerular capillaries filter much more than all other capillaries in the body combined. 4 variables (in order of their force decreasing): pgc > gc > pbs > bs. Most of these proteins carry a charge and are hydrated. Two forces push filter out: pgc and bs. Two forces oppose ultrafiltration: gc and pbs. Based on their direction, these pairs oppose one another. As water is filtered, the protein concentration increases = increased pressure. Afferent arteriole = 1/3 of system = where the majority of the ultra filtrate is for(cid:373)ed = (cid:862)(cid:374)et ultra pressure(cid:863)

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