01:146:270 Lecture Notes - Lecture 4: Polyadenylation, Interferon Alfa-2B, Intron
Document Summary
In contrast, coding sequences of most eukaryotic genes (multiple exons) are interrupted by non-coding sequences (introns). Unlike bacteria, these noncoding sequences can be as many as 10k nucleotides in length. From dna to protein 2: slide 5: Most coding human genes are broken into multiple exons and introns. Includes a lot of sequences we gained endosymbiolically over the years: can contribute to mutations. In a eukaryotic nucleus, the entire length of the gene, introns as well as exons, is transcribed into mrna (pre-mrna): after capping, and as the polymerase continues to transcribed the gene, the process of rna splicing begins: From dna to protein 3: remove the intron and then bring the exons together, and then the exons make up the gene, spliceosomes: organizations that help with the splicing of the intron. Small nuclear rna (snrna)+ protein complex: the splice junction that has to be recognized is gu and the other is ag.