01:146:270 Lecture Notes - Lecture 3: Chromatin Remodeling, Nucleosome, Atp Hydrolysis
1 Jan 2018
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Slide 3: a linker histone helps to pull nucleosomes together into a more compact chromatin fiber, h1 is not part of the octameric core but it is a histone protein. Slide 4: order of chromatin packaging gives rise to the highly condensed mitotic chromosome, sits on the scaffolding protein allowing it to loop. Chromatin and transcription 2: the more linker dna the more likely dna expression will take place, more linker dna means less compressed. Slide 7: heterochromatin and euchromatin each represent a set of different chromatin structures with different degrees of condensation, overall, heterochromatin is more condensed than euchromatin (necessary for gene expression) Slide 8: heterochromatin specific modifications allow heterochromatin to form and spread, until encounters barrier dna sequence, blocking propagation into regions of euchromatin. Chromatin and transcription 3: x-inactivation must be reversed in female germ line cells, so that all oocytes will contain two active x chromosomes.
