01:146:328 Lecture Notes - Lecture 3: Parasitophorous Vacuole, Trypanosomatida, Amastigote

• School: Rutgers University
• Department: Cell Biology and Neuroscience
• Course: 01:146:328
• Professor: A.Keating

Document Summary

New world (mexico and south america)- lutzomyia (2) blood meal from infected host>ingests amastigotes (3) in insect gut. Multiply by binary fission (4) move to mouth parts (5) next blood meal> infects host. Inside human: the tip of the promastigote attaches to the surface of a macrophage. Acidophilic: it thrives at ph 4-5. 5: host cell ruptures and the amastigotes exit then spread to other areas and infection spreads, pathology, cutaneous leishmaniasis, mucocutaneous leishmaniasis, visceral leishmaniasis, treatment. In all species is generally a drug called pentostam. Leishmania tropica: old world form of cutaneous leishmaniasis (phlebotomus) Discovered by sir william leishman and charles donovan amastigotes= ld bodies: live in macrophages throughout the body. Bone marrow and spleen increase the production of macrophages and other phagocytic cells at expense of rbcs. The macrophages being release are immature and are ineffective at managing infections.